It is a blood vessel disease that explains everything.
The photographer is MR.Cole. There is one thing in common for many of the infections bizarre symptoms.
What are the symptoms that are in common? There is an impairment in blood circulation. 40% of deaths from Covid-19 are related to cardiovascular problems, and the disease starts to look like a blood clot instead of a respiratory problem.
Blood clot was one of the many mysterious symptoms attributed to Covid-19, a disease that had initially been thought to affect the lungs in the form of pneumonia. There were reports of young people dying from coronaviruses. It was Covid toes with red or purple digits.
All the Covid-related problems were a mystery. William Li, MD, president of the Angiogenesis Foundation, says that they see blood clotting, inflammation of the heart, stroke, and encephalitis. There are a lot of seemingly unconnected phenomena that you don’t normally see with infectious diseases. A growing body of evidence supports the theory that the novel coronaviruses can cause blood clot, strokes, and heart attacks, which could explain the high prevalence of these diseases.
In a paper published in April in the scientific journal The Lancet, Mehra and a team of scientists discovered that the SARS-CoV-2 virus can cause damage to the cells that line the inside of the blood vessels. The cardiovascular system is protected by the cells of the endothelial system. In the paper, the scientists showed that people with Covid-19 have damage to their lungs, heart, kidneys, and other organs. Mandeep Mehra, MD, medical director of the Brigham and Women’s Hospital Heart, says that the virus probably affects the blood vessels.
It is very rare for a respiratory virus to infecting blood cells. The concept that is emerging is that this is more than just a respiratory illness, it is a cardiovascular illness that kills people through its involvement of the vasculature.
The respiratory tract in the nose and throat is thought to be affected by the disease. The air sacs in the lung are rich in ACE2 and the virus moves into the blood vessels. There is a respiratory virus.
It is very rare for a respiratory virus to infecting blood vessel cells. The H1N1 flu is not known to do this, and the original SARS virus did not spread past the lung. The difference between viruses that cause damage to cells in the body and those that cause damage to the lungs is that the latter are more infectious.
People start coughing when the lung tissue is destroyed by the virus. Some blood vessels are broken by the destruction of the lung tissue. It causes a local immune response and inflames the endothelium.
The lung environment is where it can replicate because it is the only place where it can cleave it. Lee says that it doesn’t really go systemic. furin is present in all of our cells, and that is a big danger because of the cleaved SARS-CoV-2]. According to Benhur Lee, a professor of microbiology at the Icahn School of Medicine at Mount Sinai, the difference between the two viruses is likely due to an extraProtein each of the viruses requires. The genetic material of the viruses can get into the cell through the use of anotherprotein, which is needed to crack open the virus. All cells, even the ones that don’t have lung tissue, have the same SARS-CoV-2Ubiquitin in them.
Many of the strange tendencies of the novel coronaviruses can be explained by an infections of the blood vessels. The cells help regulate clot formation by sending out a bunch of genes. The cells help make sure that blood flows smoothly and doesn’t get caught on the blood vessel walls. The virus could be caused by entethelial damage.
There are high rates of cardiovascular damage and heart attacks in people with Covid-19. A heart attack can be caused by inflammation in the blood vessels caused by damage to endothelial cells. This means anyone who has plaque in their blood vessels that might normally have remained stable or been controlled with medication is suddenly at a much higher risk of a heart attack. Sanjum Sethi, MD, MPH, an interventional cardiologist at Columbia University Irving Medical Center, says that the endothelial cell layer is involved in clot regulation. If that is disrupted, you could see why clot formation is possible.
People with pre-existing conditions such as high blood pressure, high cholesterol, and heart disease are at a higher risk of having a serious reaction to a virus that is supposed to only affect the lungs. All of those diseases cause damage to the cells in the blood vessels, and the infections could cause serious problems if they are not treated. Inflammation and inflammation promote plaque rupturing. It is linked to worse heart outcomes, in particular myocardial infarction or heart attack.
If the circulation is blocked, the benefits of mechanical ventilatory support are not as great. The theory could help solve the mystery of why some Covid-19 patients don’t breathe better. Ventilators help with moving air into the lungs, but it’s only one part of the equation. The exchange of oxygen and carbon dioxide in the blood is just as important to the rest of the body as it is to the individual, and that process depends on functioning blood vessels in the lungs.
Li says they saw blood clot everywhere. The particles were filling up the cell like a gumball machine. The cells start to break down and you have a layer of injured endothelium
A new paper published last week in the New England Journal of Medicine, which is co-authored by Li, found evidence of blood clot and infections in the lungs of people who died from Covid-19. The people who died from H1N1 had nine times the amount of blood in their lungs. The structure of the blood vessels was different in the Covid-19 lungs, with many more new branches likely formed after the original blood vessels were damaged.
60,000 miles worth of blood vessels are connected by endothelial cells. Is this one way that Covid-19 can impact the brain, the heart, the Covid toe? Does SARS-CoV-2 get into the bloodstream through the cells of the body? We don’t know what to do with that. It is possible that the blood vessels are the source of the virus that travels through the body to other organs.
If Covid-19 is a cardiovascular disease, the best antiviral therapy might not be antiviral therapy. In a paper that looked at nearly 9,000 people with Covid-19, Mehra showed that the use of vastatin and ACE inhibitors was linked to higher rates of survival.
We think that there is increased propensity for these viruses to cause clotting. Inflammation in general promotes that. Is this unique or is it just that the infection is more severe? I think those are good questions, but we don’t have an answer to yet.
The theory is that inflammation in the body is what causes the blood clot and other symptoms. The initial reports of blood clot, heart complications, and neurological symptoms didn’t sound alarm bells because this inflammatory reaction can occur in other respiratory illnesses and severe cases of pneumonia. The problems seen with Covid-19 appear to go beyond the inflammation experienced in other respiratory infections.
I can’t prove that this virus has an additional risk factor for blood clot, but I suspect that from what we see and what our preliminary data show. The number of requests he received as the director of the pulmonary embolism response team in April 2020 was two to three times the number in April 2019. He wants to know if there were more patients at the hospital during the peak of the Pandemic or if they really have a higher risk for blood clot.
Cholesterols and drugs are protective on the cardiovascular system. The mechanism by which they protect the cardiovascular system starts with their ability to stabilizing the endothelial. If Covid-19 is a disease of the cardiovascular system, there are drugs that can help protect against damage to the cardiovascular system. In a New England Journal of Medicine paper that looked at nearly 9,000 people with Covid-19, Mehra showed that the use of vastatin and aACE inhibitors was linked to higher rates of survival. Statins reduce the risk of a heart attack by lowering cholesterol and stabilizing plaque, so they are less likely to cause a heart attack if someone is on the drugs.
The New England Journal of Medicine paper on the effect of vastatin and aACE inhibitors on Covid-19 mortality rates has been withdrawn because of concerns over the quality of the data.
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